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KMID : 0545120140240010044
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Journal of Microbiology and Biotechnology
2014 Volume.24 No. 1 p.44 ~ p.47
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Biotransformation of Rosamicin Antibiotic into 10,11-Dihydrorosamicin with Enhanced In Vitro Antibacterial Activity Against MRSA
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Nguyen Lan Huong
Nguyen Huu Hoang
Anil Shrestha
Sohng Jae-Kyung
Yoon Yeo-Joon
Park Je-Won
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Abstract
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A biotransformation approach using microbes as biocatalysts can be an efficient tool for the targeted modification of existing antibiotic chemical scaffolds to create previously uncharacterized therapeutic agents. By employing a recombinant Streptomyces venezuelae strain as a microbial catalyst, a reduced macrolide, 10,11-dihydrorosamicin, was created from rosamicin macrolide. Its chemical structure was spectroscopically elucidated, and the new rosamicin analog showed 2-4-fold higher antibacterial activity against two strains of methicillin-resistant Staphylococcus aureus compared with its parent rosamicin. This kind of biocatalytic approach is able to expand existing antibiotic entities and can also provide more diverse therapeutic resources.
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KEYWORD
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Enhanced anti-MRSA activity, Microbial catalyst, Reduced macrolide antibiotic, Streptomyces venezuelae, 10, 11-dihydrorosamicin
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